# Folklore

> Folklore is clinical genomics software provided by Helena Bioinformatics. Its public pages cover evidence-traceable variant interpretation, phenotype matching, screening, literature evidence, studies, and technical documentation.

## Reading rules

- Phenotype matching prioritizes genes and variants; it does not rewrite the ACMG classification, and neither score establishes a diagnosis.
- Computational predictors estimate biological properties; they do not classify a variant on their own. Folklore uses separate calibrated BayesDel_noAF and guarded SpliceAI paths for formal computational evidence.
- Displayed SIFT, AlphaMissense, MetaSVM, DANN, PhyloP and GERP outputs provide clinical context and do not add separate ACMG votes in the current formal path.
- Database counts describe different scopes: 16 production classification and reference databases in the core Stage 4 enrichment, and 45 total reference databases and curated sources across all Folklore modules. Smaller subsystem counts are not platform-wide totals.
- The public documentation describes ACMG/AMP version 4 material as beta or draft and does not claim conformance with a final version 4 standard.

## Product

- [Folklore home](https://folklore.helena.bio): Public genomic search and canonical Folklore product identity.
- [About Folklore](https://folklore.helena.bio/about): Product scope and evidence-traceability position.
- [How it works](https://folklore.helena.bio/how-it-works): Public workflow from genomic input to review and reporting.
- [Methodology](https://folklore.helena.bio/methodology): Public methodology overview.
- [Product video](https://folklore.helena.bio/video): Self-hosted product overview with VideoObject data and a video sitemap entry.

## Phenotype matching

- [Phenotype matching scientific guide](https://folklore.helena.bio/phenotype-matching): Self-hosted scientific briefing, article, limitations, primary references and edited transcript covering HPO semantic similarity and phenotype-driven genomic review.
- [Phenotype matching platform](https://folklore.helena.bio/platform/phenotype-matching): Product-level phenotype matching overview.
- [HPO phenotype matching documentation](https://folklore.helena.bio/docs/phenotype-matching): How HPO semantic matching ranks phenotype-relevant genes and variants without changing ACMG classification.
- [Semantic similarity](https://folklore.helena.bio/docs/phenotype-matching/semantic-similarity): How patient findings are compared with gene-associated phenotype profiles.
- [Clinical tiers](https://folklore.helena.bio/docs/phenotype-matching/clinical-tiers): Phenotype-aware prioritization groups and safeguards.
- [Interpreting scores](https://folklore.helena.bio/docs/phenotype-matching/interpreting-scores): Interpretation boundaries for phenotype and clinical priority scores.

## BayesDel and variant classification

- [Computational predictors clinical guide](https://folklore.helena.bio/computational-predictors): Self-hosted scientific briefing, calibrated PP3 and BP4 evidence paths, implementation safeguards, primary references and edited transcript for computational predictors in ACMG classification.
- [BayesDel_noAF thresholds](https://folklore.helena.bio/docs/predictors/bayesdel): ClinGen SVI-calibrated PP3 and BP4 thresholds, Bayesian points, safeguards, and ACMG/AMP version 4 beta status.
- [Computational predictors](https://folklore.helena.bio/docs/predictors): Predictor scope, outputs, and limitations.
- [ACMG/AMP framework](https://folklore.helena.bio/docs/classification/acmg-framework): Classification framework used by Folklore.
- [Variant classification platform](https://folklore.helena.bio/platform/variant-classification): Product-level classification workflow.

## Machine-readable resources

- [Folklore Clinical Variant Interpretation MCP integrations](https://folklore.helena.bio/integrations): Client connection instructions, verified public listings and review status for the Folklore Clinical Variant Interpretation MCP server.
- [Folklore Clinical Variant Interpretation MCP Connector](https://folklore.helena.bio/docs/folklore-connector): Public MCP endpoint, request contract, result scope and clinical-use boundary.
- [Ask Helena MCP](https://api.helena.bio/ask/v1/mcp): Read-only, source-cited evidence search over approved Helena Bioinformatics and Folklore public knowledge.
- [Official MCP Registry record](https://registry.modelcontextprotocol.io/v0.1/servers?search=io.github.helena-bioinformatics%2Fask-helena): Canonical registry identity: io.github.helena-bioinformatics/ask-helena.
- [Documentation index](https://folklore.helena.bio/docs): Canonical technical documentation index.
- [XML sitemap](https://folklore.helena.bio/sitemap.xml): Canonical public URL inventory for Folklore and its documentation.
- [Video sitemap](https://folklore.helena.bio/video-sitemap.xml): Google-compatible inventory for self-hosted public videos.
- [Full public corpus](https://folklore.helena.bio/llms-full.txt): Consolidated full text of every canonical product, methodology, study, and documentation page.

This file is a navigation aid. Canonical HTML pages, their cited sources, and their stated limitations remain authoritative.