Programmatic variant evidence
A clinical variant interpretation API for agent workflows
Folklore Clinical Variant Interpretation MCP provides a public machine interface for supported GRCh38 germline variants. It returns typed outcomes and structured evidence so an agent can branch deterministically instead of relying on model memory.
Try the task
Resolve rs80357914, and do not select an allele if the result is ambiguous.
Connect through https://api.helena.bio/folklore/v1/mcp or follow the connector guide.
Contract first
The endpoint uses stateless Streamable HTTP. A request contains the fixed GRCh38 assembly and one public variant expression. A response preserves resolved, ambiguous, not-found, invalid, unsupported and temporarily unavailable states.
- Endpoint: https://api.helena.bio/folklore/v1/mcp
- Tool: search_variant_evidence
- Transport: Streamable HTTP
- Authentication: none
- Operations: public and read-only
Compose evidence and literature
After a variant resolves, reuse its canonical key with search_variant_literature. Retrieve a returned PMID with get_publication_details, or use search_literature_corpus for a broader source-linked literature question. Publication association remains distinct from pathogenicity and causality.
Public scientific boundary
Folklore Clinical Variant Interpretation MCP accepts public variant-level queries only. Do not send patient, phenotype, family, segregation or private case data. Results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.