Model Context Protocol
Connect Folklore Clinical Variant Interpretation MCP to your AI client
Folklore Clinical Variant Interpretation MCP is the official public, read-only MCP server from Helena Bioinformatics. It provides supported GRCh38 germline variant interpretation with structured Folklore evidence, automated ACMG/AMP decision support, transparent provenance and related scientific literature. It does not provide patient diagnoses or treatment recommendations, and its results require review by a qualified genetics professional.
Connection contract
Use Streamable HTTP. Folklore does not require an account, API key or OAuth flow.
- Endpoint
- https://api.helena.bio/folklore/v1/mcp
- Tools
- search_variant_evidence, search_variant_literature, get_publication_details
- Authentication
- None
- Registry name
- io.github.helena-bioinformatics/folklore
Direct client connections
Every client below reaches the same endpoint and tool. A tested custom connection means that Folklore was connected in that client. It does not mean the provider has approved a public directory listing.
ChatGPT
Tested custom appCreate a custom MCP app and use the Folklore endpoint. No authentication fields are required.
Claude
Tested custom connectorAdd a custom connector with the Folklore endpoint. The connection does not require an account or API key.
Codex and Cursor
Direct HTTP configurationAdd a server named folklore with the url field shown below.
VS Code
Direct HTTP configurationAdd a server named folklore with type http and the Folklore endpoint as its url.
Gemini CLI
Direct HTTP configurationAdd a server named folklore in the Gemini CLI MCP settings, select HTTP transport and use the Folklore endpoint.
Perplexity, Grok and Windsurf
Remote connector configurationUse the same endpoint in the client remote MCP or custom connector settings. Select Streamable HTTP when the client asks for a transport.
Codex and Cursor
{
"mcpServers": {
"folklore": {
"url": "https://api.helena.bio/folklore/v1/mcp"
}
}
}VS Code
{
"servers": {
"folklore": {
"type": "http",
"url": "https://api.helena.bio/folklore/v1/mcp"
}
}
}Verified public listings
These pages were publicly reachable when this guide was reviewed on 13 August 2026. The Official MCP Registry is the canonical machine-readable publication source. Aggregator health labels do not replace the Folklore health and readiness checks.
Official MCP Registry
Canonical registry identity io.github.helena-bioinformatics/folklore. Version 1.2.2 is the current published release.
Glama
The listing is owned by Helena Bioinformatics and uses the canonical Folklore endpoint.
MCPBeat
Automatically discovered listing. Registry metadata can take time to refresh after a release.
mcpservers.org
Editorially approved public listing. Its durable slug remains stable while the display-name update is processed.
Submitted and under review
Submission is recorded separately from publication. The links below show the durable public review item where one exists. ChatGPT and Claude directory submissions are complete, but public directory approval has not been independently verified. Smithery publication is deferred.
Ask a bounded question
Example: Use Folklore to classify ENST00000226413.5:c.317A>G under ACMG/AMP and summarize the evidence, provenance and limitations.
Supported input includes GRCh38 coordinates, selected genomic, coding and protein HGVS, SPDI and rsID for one nuclear germline SNV or simple indel smaller than 50 base pairs. Ambiguous expressions return candidates for the user to choose.
Clinical boundary
Folklore returns variant-level decision support for qualified genetics professionals. It accepts no patient, phenotype, family, segregation or case context. The automated classification is not a diagnosis, treatment recommendation or standalone clinical report.
A qualified professional must review the evidence and confirm clinically significant findings before clinical use.