Prepare the Evidence Before Clinical Review
Interpreting genetic variants requires years of specialized training, deep clinical knowledge, and the kind of judgment that cannot be automated. What can be automated is the hours spent cross-referencing databases, searching literature, and compiling evidence before your interpretation begins.
Folklore prepares the evidence for review; the geneticist retains the clinical judgment.
The Real Bottleneck
Manual database searches, literature review, and evidence compilation consume much of the time required for variant interpretation.
Without Folklore
Per case, typical workflow
With Folklore
Same case, same rigor
Same evidence. Same standards. Your clinical judgment throughout.
Clear Division of Responsibility
Folklore's scope ends at evidence preparation and rule application. Clinical interpretation remains with the geneticist.
What Folklore Does
Automated evidence gathering
Cross-references ClinVar, gnomAD, dbNSFP, and ClinGen in seconds
Searches millions of PubMed publications for relevant literature
Maps ACMG/AMP criteria against variant evidence systematically
Matches patient phenotype (HPO) against gene-disease profiles
Formats structured reports with full evidence attribution
Completes evidence preparation in minutes, not days
What You Do
Clinical expertise that cannot be automated
Applies clinical judgment that no algorithm can replicate
Integrates patient history, family context, and clinical presentation
Evaluates edge cases where guidelines require expert interpretation
Makes the final classification decision on every variant
Communicates findings to patients and referring physicians
Determines clinical actionability and management recommendations
Your Expertise, Amplified
Folklore reduces the time spent retrieving and organizing evidence before clinical review.
Deeper Evidence Access
Each variant is annotated with 60+ data points from established databases. Literature search covers millions of publications with pre-extracted gene and variant mentions.
Consistent, Reproducible Workflow
The pipeline follows the configured search steps for each case and records the resulting evidence.
More Time for Complex Cases
Reducing routine evidence gathering leaves more review time for rare variants, conflicting evidence, novel gene-disease associations, and difficult phenotypes.
Audit Trail
The report records the databases queried, criteria applied, and publications cited so the reviewer can trace each evidence source.
What Always Stays in Your Hands
The following decisions remain with a qualified clinical geneticist.
Folklore will never:
Make a diagnostic decision
Override your clinical judgment
Classify a variant without your confirmation
Replace the context only you have about your patient
Communicate results to patients or clinicians
Determine treatment or management plans
Folklore prepares the evidence. The geneticist makes the clinical decision.
Review a Case Workflow
A demo shows the evidence and report that reach the geneticist for review.