Evidence source and decision support
Folklore and ClinVar answer different questions
ClinVar is a public archive of submitted relationships between variants and health. Folklore Clinical Variant Interpretation MCP can expose available ClinVar assertions inside a broader structured variant-evidence result and return automated ACMG/AMP decision support.
Try the task
Show the automated classification, then list available ClinVar assertions separately.
Connect through https://api.helena.bio/folklore/v1/mcp or follow the connector guide.
Do not collapse archive evidence into one label
A submitted assertion, an aggregate ClinVar state and an automated classification are different objects. A reviewable workflow should identify the source, review status, conflicts, applied criteria and data versions instead of presenting them as interchangeable.
- Use ClinVar assertions as source evidence when available.
- Keep the automated Folklore result separately labelled.
- Preserve conflicting or unavailable states.
- Review the evidence before clinical reporting.
Primary reference
For ClinVar scope and submission history, see Landrum et al., ClinVar: improving access to variant interpretations and supporting evidence, doi:10.1093/nar/gkx1153.
Public scientific boundary
Folklore Clinical Variant Interpretation MCP accepts public variant-level queries only. Do not send patient, phenotype, family, segregation or private case data. Results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.