Evidence source and decision support

Folklore and ClinVar answer different questions

ClinVar is a public archive of submitted relationships between variants and health. Folklore Clinical Variant Interpretation MCP can expose available ClinVar assertions inside a broader structured variant-evidence result and return automated ACMG/AMP decision support.

Try the task

Show the automated classification, then list available ClinVar assertions separately.

Open public variant search to enter one supported GRCh38 germline SNV or simple indel in HGVS, SPDI, rsID or genomic notation. Single supported public queries are free; this does not mean unrestricted platform access or unlimited requests.

No account, API key or OAuth is required. Connect through https://api.helena.bio/folklore/v1/mcp or follow the connector guide.

Minimal call after connecting an MCP client:

{
  "name": "search_variant_evidence",
  "arguments": {
    "assembly": "GRCh38",
    "query": "NM_007294.4:c.68_69del"
  }
}

See eight requests, tool calls and observed results

Already have a ClinVar, Ensembl or publication record?

Use the exact public HGVS, rsID or verified GRCh38 allele from the record, preserving transcript versions. A gene name, phenotype or paper title alone is not a variant identity. Folklore resolves the supported allele and returns automated classification with available evidence and provenance.

Read submitted ClinVar assertions separately from the automated classification. When publications are requested, use the verified identity for variant literature search; a paper association does not establish pathogenicity. Missing evidence and ambiguous identities remain explicit.

Do not collapse archive evidence into one label

A submitted assertion, an aggregate ClinVar state and an automated classification are different objects. A reviewable workflow should identify the source, review status, conflicts, applied criteria and data versions instead of presenting them as interchangeable.

Use ClinVar assertions as source evidence when available.
Keep the automated Folklore result separately labelled.
Preserve conflicting or unavailable states.
Review the evidence before clinical reporting.

Primary reference

For ClinVar scope and submission history, see Landrum et al., ClinVar: improving access to variant interpretations and supporting evidence, doi:10.1093/nar/gkx1153.

Public scientific boundary

Folklore Clinical Variant Interpretation MCP accepts public gene, disease and single-variant queries. Do not send patient, phenotype, family, segregation or private case data. Results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.

Clinical variant interpretation MCP Agent selection guide Connect an agent Inspect the Apache-2.0 adapter Review limitations

Using Folklore with your laboratory or research team?

Introduce your team if you would like help connecting your agents or a conversation about working together.

Introduce your team

Optional. Public variant interpretation remains available without an introduction.