Documentation / Literature Evidence / Evidence Labels
Evidence Labels
Strong, Moderate, Supporting, and Weak are Folklore literature-triage labels. They summarize detected search signals so a geneticist can prioritize reading. They are not ACMG/AMP evidence strengths and do not apply a classification criterion.
Label Definitions
Strong
Prioritized for early review because the abstract-level record contains both variant-specific and experimental signals.
Detected signals: Exact variant indicator and functional-data indicator are both present.
Moderate
Potentially useful variant-specific or experimental context is present, but the other signal is absent.
Detected signals: Either the exact variant indicator or the functional-data indicator is present.
Supporting
The paper may help assess gene-phenotype relevance but has no detected exact-variant or functional signal.
Detected signals: A query gene and at least one patient phenotype name match.
Weak
The publication remains in the review set as lower-priority background or a possible extraction miss.
Detected signals: The stronger combinations above are not present.
What the Indicators Establish
Variant indicator
Shows that compatible gene and variant notation were detected in the indexed title or abstract record. It does not establish that the paper studied the same transcript, allele, phenotype, or inheritance context.
Functional indicator
Shows that MeSH metadata or abstract language suggests experimental work. It does not validate the assay or establish a well-established functional effect.
Before Applying Clinical Evidence
Read the full methods and results, not only the PubMed abstract.
Confirm transcript, genomic build, allele, zygosity, inheritance, and phenotype context.
Evaluate assay controls, calibration, biological relevance, and replication before considering functional criteria.
Check publication corrections, expressions of concern, and retraction status at the source.
Apply the current ACMG/AMP and ClinGen specifications independently of the Folklore triage label.
Do Not Translate Labels into ACMG Codes
A Strong literature label is not PS3, a Supporting label is not PP4, and no label is PP5. The automated Variant Analysis classifier and the clinician's evidence review remain separate from literature triage.