Variant evidence review
Stop at ambiguity before classification or literature lookup
A plausible-looking HGVS string is not enough to identify a unique genomic allele. Assembly, transcript version and reference sequence can matter. Safe agents branch on the returned state and never choose a candidate by guesswork.
Agent question
Can this public HGVS expression be resolved to one supported GRCh38 allele?
Deterministic state handling
Continue only for a resolved result. For ambiguous results, show returned candidates and ask the user to select. Report not found, invalid, unsupported and temporarily unavailable states directly.
Prevent identity drift
Do not substitute a nearby variant, silently change assembly, remove a transcript version or search literature for a guessed allele.
- Echo the exact input
- Record the declared assembly
- Preserve transcript and version
- Show returned candidates without ranking them
- Continue only after explicit disambiguation
Public references
Clinical and data boundary
Folklore Clinical Variant Interpretation MCP is published by Helena Bioinformatics. It accepts public variant-level queries only, not patient, phenotype, family, segregation or private case data. Its results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.