Evidence criteria
Read the criteria, the evidence and the limits together
An automated ACMG/AMP result is reviewable only when the applied criteria remain connected to source evidence, availability states, provenance and the exact resolved variant identity.
Try the task
Explain the returned ACMG/AMP criteria for ENST00000226413.5:c.317A>G without inventing missing evidence.
Connect through https://api.helena.bio/folklore/v1/mcp or follow the connector guide.
Evidence availability is part of the result
Available, unavailable and absent evidence are not synonyms. An agent should preserve the state returned by the tool and avoid converting a missing field into negative evidence.
- Report only criteria returned by the public contract.
- Cite source links and data versions when present.
- Do not reconstruct unpublished thresholds or implementation logic.
- Separate automated decision support from professional conclusion.
Framework reference
The ACMG/AMP sequence-variant interpretation framework is described by Richards et al., Standards and guidelines for the interpretation of sequence variants, doi:10.1038/gim.2015.30.
Public scientific boundary
Folklore Clinical Variant Interpretation MCP accepts public variant-level queries only. Do not send patient, phenotype, family, segregation or private case data. Results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.