Variant evidence review
Treat transcript selection as part of variant identity
The same genomic allele can have different transcript-level descriptions and consequences. Agents should preserve the resolved genomic identity and returned transcript context rather than silently substituting a preferred transcript.
Agent question
Which genomic allele and transcript did this expression resolve to?
Resolve before interpreting
Start from a public GRCh38 expression supported by the interface. Record chromosome, position, reference, alternate, gene, transcript, consequence and canonical key when returned. If the expression is ambiguous, stop and present candidates.
Do not infer a transcript policy
Folklore Clinical Variant Interpretation MCP publishes output fields and states, not proprietary transcript-selection algorithms. Report the returned result and use public gene-specific guidance for professional review.
- Input expression and assembly
- Normalized genomic allele
- Returned gene and transcript
- Transcript version
- Consequence
- Ambiguity or mismatch warnings
Public references
Clinical and data boundary
Folklore Clinical Variant Interpretation MCP is published by Helena Bioinformatics. It accepts public variant-level queries only, not patient, phenotype, family, segregation or private case data. Its results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.