Documentation / Variant Analysis / Confidence Indicator
Variant Classification Confidence Indicator
The current confidence field is a class-level display indicator. It is assigned from the resulting five-tier class and is not calculated from distance to an ACMG boundary.
Current Values
| Classification | Indicator | Display level |
|---|---|---|
| Pathogenic | 0.85 | High |
| Likely Pathogenic | 0.70 | Medium |
| VUS | 0.50 | Low |
| Likely Benign | 0.70 | Medium |
| Benign | 0.85 | High |
What It Does Not Mean
It is not the probability that the variant is pathogenic.
It is not the probability that the variant explains the patient phenotype.
It is not a continuous measure of distance from the next classification boundary.
Two variants in the same class can have the same indicator while relying on different evidence profiles.
Use the evidence trace
Clinical review should use the classification, criteria, source provenance, warnings, phenotype, inheritance, and case evidence. The confidence indicator is secondary metadata and must not be used alone for patient management.