Documentation / Variant Analysis / Review and Reclassification
Clinical Review and Variant Reclassification
Folklore separates the pipeline classification from the geneticist's reviewed classification. An authorized reviewer can record a different five-tier class with a clinical justification while the original pipeline result remains preserved.
Review Workflow
1. Review the evidence
Assess the pipeline class, criteria, source provenance, patient phenotype, inheritance, family evidence, and relevant literature.
2. Record the reviewed class
Select a five-tier class and provide a clinical justification. The first pipeline class is preserved as the original result.
3. Use the effective class
While an override is active, lists and summaries use the reviewed class and expose the override metadata.
4. Revert when appropriate
The reviewed class can be removed, restoring the preserved pipeline class as the active result.
Auditability
Reclassification records the original class, reviewed class, justification, reviewer attribution, and timestamp. Reverting a reviewed class is also audited. The automated evidence is not rewritten, so reviewers can distinguish what the pipeline produced from the active clinical decision.
Important distinction
A reviewed class is a clinical decision, not a retraining event and not a hidden modification of the classifier. Future pipeline runs may change as reference data or classifier versions change, while the recorded review remains attributable and reversible.