ACMG/AMP classification
Classify a germline variant and inspect the evidence
Start with one public variant expression. Folklore Clinical Variant Interpretation MCP resolves the identity, returns automated ACMG/AMP decision support and keeps the evidence, provenance and limitations attached to the result.
Try the task
Classify ENST00000226413.5:c.317A>G under ACMG/AMP and show the evidence.
Connect through https://api.helena.bio/folklore/v1/mcp or follow the connector guide.
A reviewable classification workflow
A useful agent workflow must do more than produce a label. It should preserve the normalized variant identity, applied criteria, available source evidence, data versions and limitations so a qualified professional can review the path to the result.
- Resolve the public variant expression on GRCh38.
- Stop if resolution is ambiguous instead of choosing an allele.
- Report the automated classification and applied criteria exactly as returned.
- Separate available, unavailable and absent evidence.
- Keep the professional-review boundary visible.
Machine interface
Call search_variant_evidence or use the classify_germline_variant workflow prompt. The public endpoint is read-only and requires no account or API key.
Public scientific boundary
Folklore Clinical Variant Interpretation MCP accepts public variant-level queries only. Do not send patient, phenotype, family, segregation or private case data. Results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.