Variant of uncertain significance
Review a VUS without turning uncertainty into a clinical claim
A VUS means the available evidence is insufficient or conflicting. It does not mean that a variant is known to cause disease, and it does not mean that the variant is known to be benign.
Try the task
Review rs80357914 as a VUS. If the identifier is ambiguous, show the candidates and stop.
Connect through https://api.helena.bio/folklore/v1/mcp or follow the connector guide.
Evidence before interpretation
Folklore Clinical Variant Interpretation MCP resolves the public variant identity before returning automated ACMG/AMP decision support. The output can include applied criteria, available ClinVar assertions, available population-frequency evidence, computational predictions, provenance and limitations.
- Verify the allele and transcript.
- Preserve the current classification and evidence state.
- Do not infer missing evidence.
- Keep literature association separate from pathogenicity.
- Require qualified professional review.
Ambiguous identifiers
Some identifiers can map to more than one allele. The safe result is a candidate list and a request for exact HGVS or chromosome, position, reference and alternate alleles. Automatic selection would risk attaching evidence to the wrong variant.
Public scientific boundary
Folklore Clinical Variant Interpretation MCP accepts public variant-level queries only. Do not send patient, phenotype, family, segregation or private case data. Results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.