Variant evidence review
Automated variant classification does not establish a patient diagnosis
ACMG/AMP classification evaluates evidence about a variant. Clinical diagnosis and management require patient-specific findings, phenotype, family history, segregation, laboratory context and qualified professional judgment outside the public MCP boundary.
Agent question
What can an agent safely report from a public variant-level result?
Safe output boundary
An agent may report the resolved public variant, current automated classification, applied criteria, source-linked evidence, provenance and limitations. It must not convert that result into diagnosis, prognosis, treatment or reproductive advice.
Data that must not be sent
Do not send patient identifiers, phenotype, family history, segregation, private case notes or other patient context to Folklore Clinical Variant Interpretation MCP.
- Public variant expression only
- No patient or case data
- No autonomous diagnosis
- No treatment recommendation
- Explicit uncertainty and unavailable evidence
- Qualified professional review
Public references
Clinical and data boundary
Folklore Clinical Variant Interpretation MCP is published by Helena Bioinformatics. It accepts public variant-level queries only, not patient, phenotype, family, segregation or private case data. Its results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.