Variant evidence review
Unavailable evidence is not negative evidence
A source or resolution service can be temporarily unavailable even when a variant exists. Safe agent workflows report the returned availability state and avoid inventing evidence, criteria or a classification.
Agent question
Which evidence is unavailable, and can the current result support any conclusion?
Keep outcome layers separate
Distinguish a domain outcome such as unavailable resolution from a transport or adapter failure. Preserve the machine-readable state, provenance and retry guidance when present.
- Do not convert unavailable into absent
- Do not convert timeout into not found
- Do not infer criteria from model memory
- Retry only within documented limits
- Retain qualified professional review
Report what remains reviewable
If part of a resolved evidence record is unavailable, report the available fields and the unavailable source separately. Do not present a partial record as complete.
Public references
Clinical and data boundary
Folklore Clinical Variant Interpretation MCP is published by Helena Bioinformatics. It accepts public variant-level queries only, not patient, phenotype, family, segregation or private case data. Its results are automated decision support for qualified professional review, not a diagnosis or treatment recommendation.